Separate profiles or single profiles?

[JarrettGoetz]

Tealium community, looking for advice on the best way to architect our Tealium environment for both EventStream and AudienceStream.  If we were going to be running 500-1,000 distinct clients of ours in our Tealium account, how would you structure the profiles with regard to either a separate profile for each web properly/business, or put them all into a single Tealium profile for certain efficiencies and delineate between clients/properties in other ways?  Or, something else?

Thanks for your thoughts, and let me know what clarifying questions you may have?